Capsaicin causes pain and heat when eating chillies. Researchers have now discovered capsaicin-like molecules in human nerve cells.
Read If Chilifan or not, pain patients could soon owe the small red hotmakers new drugs in the fight against their suffering. Thanks to the chili ingredient capsaicin, US researchers have come to grips with a previously unknown type of pain molecule. These are formed by injuries to the body and attach to the same recipients as the capsaicin, which causes pain and heat sensation when eating chillies. Building on this knowledge, the scientists developed two drugs that block these receptors? And to stop the pain in this way, the researchers report to Kenneth Hargreaves from the University of Texas Health Science Center in San Antonio. Some chilies burn only pleasant on the tongue, others can cause hellish pain. Responsible is an ingredient called capsaicin. If he docks on to certain receivers, the so-called TRPV1 receptors, the affected nerve cells send pain and heat signals to the brain. Hargreaves and his colleagues were surprised, however, that the same receptors in patients with chronic pain on permanent reception were switched. Your guess: The nerve cells form capsaicin-like molecules that cause permanent pain.

To test this thesis, they heated skin flaps of laboratory mice in a 43 degrees Celsius hot water bath? From this temperature, people feel pain. The fluid would then theoretically have been the pain-causing molecules. The researchers now brought the fluid into contact with nerve cells from two different mouse species: the nerve cells of normal mice responsible for the pain transmission had responded to capsaicin in preliminary experiments? and now showed this reaction to the water. The other nerve cells came from mice in which the scientists had switched off a gene that was responsible for the generation of TRPV1 receptors. As a result, these neurons did not respond to capsaicin in the preliminary experiments? and now remain inactive on contact with the fluid.

The theory of the researchers had been confirmed, and now that they knew what they had to look for, they also found what they were looking for: two previously unknown fatty acids are the ones responsible. "This is a big breakthrough in understanding pain mechanisms and how to treat them effectively, " says Hargreaves. "Drugs that block either the production or the action of these substances could make new therapies possible for many diseases and pain disorders, such as arthritis, fibromyalgia and cancer-related pain." Two such drugs are currently being tested by the team. The advantage of such drugs: they would eliminate the root evil and, unlike opioids that affect the central nervous system, do not addict, the researchers explain.

Kenneth Hargreaves (University of Texas Health Science Center, San Antonio) et al .: Journal of Clinical Investigation, online publication of April 26, 2010 ddp / Mascha Schacht advertisement


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