To test this thesis, they heated skin flaps of laboratory mice in a 43 degrees Celsius hot water bath? From this temperature, people feel pain. The fluid would then theoretically have been the pain-causing molecules. The researchers now brought the fluid into contact with nerve cells from two different mouse species: the nerve cells of normal mice responsible for the pain transmission had responded to capsaicin in preliminary experiments? and now showed this reaction to the water. The other nerve cells came from mice in which the scientists had switched off a gene that was responsible for the generation of TRPV1 receptors. As a result, these neurons did not respond to capsaicin in the preliminary experiments? and now remain inactive on contact with the fluid.
The theory of the researchers had been confirmed, and now that they knew what they had to look for, they also found what they were looking for: two previously unknown fatty acids are the ones responsible. "This is a big breakthrough in understanding pain mechanisms and how to treat them effectively, " says Hargreaves. "Drugs that block either the production or the action of these substances could make new therapies possible for many diseases and pain disorders, such as arthritis, fibromyalgia and cancer-related pain." Two such drugs are currently being tested by the team. The advantage of such drugs: they would eliminate the root evil and, unlike opioids that affect the central nervous system, do not addict, the researchers explain.Kenneth Hargreaves (University of Texas Health Science Center, San Antonio) et al .: Journal of Clinical Investigation, online publication of April 26, 2010 ddp / science.de? Mascha Schacht advertisement