Reading Fats with high levels of saturated fat such as butter or the fat in meat dishes interfere with a body's regulatory mechanism: they cause the brain to signal the body's cells to ignore the signals of the hormones leptin and insulin. These two messengers are used to regulate the weight, so tell the body when there is enough food. So if you eat a lot of such fat, you still tend to eat more. This mechanism has been explored by researchers led by Deborah Clegg from the University of Texas at Dallas in rat experiments. In the experiments, the scientists either fed fats with high levels of saturated fatty acids, which include butter and other dairy products, fats with monounsaturated fatty acids or fats with a high percentage of oleic acid, which are high in, for example, olive or grape seed oil Concentrations are included. This enabled the scientists to study the effects of all types of fats, which also play a role in human nutrition. The total calorie intake was the same in all cases. The animals ingested the fats directly through the diet, through infusions into the bloodstream, or through direct injection into the brain.
The evaluation showed a clear effect of saturated fatty acids: these reduced the sensitivity of the cells for the hormones leptin and insulin in the animals, the researchers observed. This left the activation of the signaling pathways out, which otherwise trigger a feeling of satiety. On the other hand, unsaturated fatty acids such as those present in vegetable edible oil did not cause such a reaction. The fats with high levels of saturated fatty acids directly affected the brain's response to this pathway, the experiments showed.
Although the results were based on experiments with rats, the study provides further evidence for the recommendation to pay close attention to the proportion of saturated fatty acids in the diet. These seduced to eat more, explains Clegg. It has been known for some time that a very high-fat diet reduces the sensitivity to insulin, which can lead to long-term diabetes.
Deborah Clegg (University of Texas at Dallas) et al .: Journal of Clinical Investigation. (Vol. 119, p. 2577). ddp / science.de - Ulrich Dewald advertisement