Credit: Ozaki Lab, Brigham and Women's Hospital
Reading aloud An operation not only affects the target organ itself: to achieve it, surgeons must cut through the outer layers of the body, which consist to a large extent of fatty tissue. US researchers have now observed in mice that a low-fat diet three weeks before surgery positively affect the healing-related reactions of adipose tissue. Presumably, such diets in humans could accelerate the recovery from interventions and avoid complications, say researchers around Keith Ozaki of Harvard Medical School in Bosten. The experimental animals of the researchers were generally used to a diet that corresponds to the typical Western diet of humans - with a high fat content: 60 percent of the energy in the diet of the mice came from fat. Three weeks before the start of the experiments, however, the researchers then changed the diet of some animals: They got instead of the hearty food a diet in which only ten percent of the calories came from fat. In all experimental animals, the researchers subsequently performed experimental procedures that correspond to human operations.

Less inflammatory processes after diet

The investigations of the researchers during the recovery of the rodents showed: The traumatized by the operation of fatty tissue of all experimental animals showed signs of inflammatory processes. These can have negative effects on surrounding tissue and thus disrupt healing. The adipose tissue in the wound area of ​​the animals that had received the three-week diet prior to surgery showed comparatively less signs of stress, so had better healing parameters. Apparently, the diet had favorably influenced the properties of fatty tissue. "Our results show that the quality of our adipose tissue is important in recovery processes, " summarizes Ozaki.

The scientists now propose to investigate the relationship between the fat content in food before surgery and its effects on recovery in humans. "It is well-known that minimizing tissue stress during surgery can accelerate patient recovery, " says Ozaki. "So far, however, the focus has been on the affected organs, such as heart, liver and blood vessels - the fatty tissue through which surgeons have to cut, but so far rather less attention." display

The current results emphasize that this tissue is important and that its healing parameters seem to be influenced. The omission of certain foods from upcoming surgeries could be a simple but effective way to protect the body from the consequences of surgery, say the scientists.

Keith Ozaki from (Harvard Medical School, Bosten) et al .: Surgery, doi: 10.1016 / j.surg.2012.11.001 © science.de - Martin Vieweg

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