In earlier studies, the University of Louisville scientists have been able to demonstrate the positive effects of so-called microvascular constructs (MVCs). These tiny fragments of blood vessels stimulate blood flow when introduced into the body and can therefore be used to prevent scarring.
With this in mind, researchers solved MVCs in a collagen gel. This MVC and collagen are combined with the device prior to implantation. "The presence of MVCs and collagen changed the way tissue formed around the implant. The formation of scar tissue was limited because the activity of the blood vessels was very high, "explains Williams. "Together, we could ensure a sustainable blood supply over time, " he adds. Collagen, as a structural protein of connective tissue, also has another advantage: it reduces the number of white blood cells that normally cause inflammatory responses when an implanted device interacts with the surrounding tissue.
So far, scientists have used animal models as experimental objects. Currently they are working on testing the system on people. displayStuart Williams (University of Louisville) et al .: Journal of Biomedical Materials Research, doi: 10.1002 / jbm.a.32925 ddp / science.de? Theresa Klüber