Pacemakers and other implants are perceived as foreign by the body and a scar tissue forms around it. A system consisting of vascular components and proteins will in future serve as a bridge between the body and the device used and reduce the rejection of the body.
Reading aloud American scientists have developed a system that connects transplanted devices such as pacemakers or probes to measure blood glucose levels with surrounding tissue. The system consisting of vascular components and proteins serves as a bridge between the body and the device used. This reduces the rejection of the body and improves the longevity and function of the devices. "One of the biggest problems with transplanted devices is the body's natural defense reaction. He recognizes medical devices as alien and forms a scar, "says study leader Stuart Williams. This process takes place on all transplanted devices, from the pacemaker to the glucose sensors needed to monitor blood glucose in diabetics. "Scars are barely traversed by blood and inhibit the connection from the device to the body. That's how it works, "Williams explains.

In earlier studies, the University of Louisville scientists have been able to demonstrate the positive effects of so-called microvascular constructs (MVCs). These tiny fragments of blood vessels stimulate blood flow when introduced into the body and can therefore be used to prevent scarring.

With this in mind, researchers solved MVCs in a collagen gel. This MVC and collagen are combined with the device prior to implantation. "The presence of MVCs and collagen changed the way tissue formed around the implant. The formation of scar tissue was limited because the activity of the blood vessels was very high, "explains Williams. "Together, we could ensure a sustainable blood supply over time, " he adds. Collagen, as a structural protein of connective tissue, also has another advantage: it reduces the number of white blood cells that normally cause inflammatory responses when an implanted device interacts with the surrounding tissue.

So far, scientists have used animal models as experimental objects. Currently they are working on testing the system on people. display

Stuart Williams (University of Louisville) et al .: Journal of Biomedical Materials Research, doi: 10.1002 / jbm.a.32925 ddp / Theresa Klüber


Recommended Editor'S Choice