Read The balance of two hormones is crucial to prevent premature birth: During pregnancy, the two estrogens estradiol and estriol are in balance. However, as soon as one of them gains the upper hand, contractions come to an end, Australian researchers have discovered around Roger Smith at John Hunter Hospital in Newcastle. Accordingly, by observing the estradiol and estriol ratios during pregnancy, it would not only be possible to predict the date of birth. By specifically influencing the hormone level, one could even postpone the contractions to the front or to the rear and prevent premature births in the future. The scientists examined the hormone balance of 500 pregnant women. In all, the proportion of estradiol and estriol was in equilibrium until shortly before birth. But then the estradiol content increased rapidly, and soon afterwards labor began. The production of estradiol, in turn, is due to another hormone, corticoliberin, which is constantly increasing in pregnancy. Corticoliberine acts on the adrenals of the fetus and stimulates them to release steroids. The steroids then initiate estradiol production in the placenta.
This would also explain why pregnancy in pregnant women continues even after the fetus dies in the womb: "In this case, the estradiol content would rapidly decrease, thereby dominating the estriol and inducing the onset of labor, " explains Smith. From the relationship of both hormones and its time course can be concluded on the one hand on the birth time point. On the other hand, medics could administer pregnant women one of the two hormones to postpone the onset of labor and thus to prefer the date of birth or to delay a premature birth.
Roger Smith (John Hunter Hospital, Newcastle, Australia) et al .: Journal of Clinical Endocrinology & Metabolism, Online Advance Registration ddp / science.de? Masha's shaft