Thus, this activation proceeds as follows: If a naive T cell, that is, a non-combatant T cell, comes into contact with a potential intruder, such as a fraction of a bacterial cell, it begins to produce a vitamin D recognition protein. This is then extended like a kind of antenna and tests if vitamin D is available. If the antenna registers the vitamin, an entire reaction cascade occurs. In the end, the T cell replicates, forming hundreds of identical cells, all focused on the spotted pathogen. If vitamin D is missing, however, this mobilization does not take place.
The results give previously unknown insights into the work of the immune system, the researchers emphasize. So you can help regulate the body's response in the future? not only in controlling infections, but also in suppressing excessive immune responses, such as those found in autoimmune diseases or rejection following organ transplantation. In both cases, activated T cells multiply explosively and produce inflammation that can have disastrous consequences for the body. By the way, in mice, the popular laboratory model, is there not a connection between vitamin D and T cells? presumably because the nocturnal hairy mice do not have much vitamin D available anyway, so it would not have been beneficial if this substance played such an important role in their immune system.Carsten Geisler (University of Copenhagen) et al .: Nature Immunology, online pre-publication, doi: 10.1038 / ni.1851 ddp / science.de? Ilka Lehnen-Beyel advertisement